Caspase-10 Inhibitor AEVD-FMK | 1112

A synthetic peptide inhibitor that inhibits caspase-10 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-AEVD-FMK is a cell-permeable, irreversible caspase-10 inhibitor.

1112 | Caspase-10 Inhibitor AEVD-FMK DataSheet

Alternate Name/Synonyms: Z-AEVD-FMK, Caspase-10 Inhibitor (fluoromethylketone)

Appearance: Liquid

Formulation: DMSO ( 2 mM)

CAS Number: N/A

Structure Available?: No

Peptide sequence: Z-Ala-Glu(OMe)-Val-Asp(OMe)-FMK

Salt Form: No

Molecular Formula: C₂₈H₃₉N₄O₁₀F

Molecular Weight: 610.63

Cell-Permeable?: Yes

Purity: >95% by HPLC

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A caspase-10 inhibitor

MDL Number: MFCD03453601

PubChem CID: 44135225

SMILES: CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(C)NC(=O)OCC1= CC=CC=C1

InChi: InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5) 33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10- 18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33, 38)

InChi Key: CHZRBQFKZDGMTP-UHFFFAOYSA-N