Caspase-10 polyclonal Antibody | BS90184

Caspase-10 polyclonal Antibody | BS90184 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC IP FC

Application Range: WB:1:1,000-1:2,000 FC:1:50-1:100 IHC:1:50-1:200

Background: Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Caspase-10 polyclonal Antibody detects endogenous levels of Caspase-10 protein.

Molecular Weight: 59 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CASP-10, FLICE2, CASP10, ALPS2, Apoptotic protease Mch-4, CASP 10, CASP-10, CASP10, CASPA, Caspase 10 apoptosis related cysteine peptidase, Caspase-10 subunit p12, FADD like ICE2, Fas associated death domain protein, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE 2, FLICE2, ICE like apoptotic protease 4, ICE-like apoptotic protease 4, Interleukin 1B converting enzyme 2, MCH 4,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: