Caspase 14 p10 polyclonal Antibody | BS5643

Caspase 14 p10 polyclonal Antibody | BS5643 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p19 and p10 subunits by caspase-8. Caspase-14 may not play a role in apoptosis, but instead may regulate keratinocyte differentiation. Expression of caspase-14 may protect from psoriasis and irradiation damage. Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Caspase 14 p10 polyclonal Antibody recognizes endogenous levels of total caspase-14 protein and the p10 subunit of mature caspase-14.

Molecular Weight: ~ 10, 27 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Caspase14; Caspase-14; CASP-14; Caspase-14 subunit p10; CASP14

Immunogen: Synthetic peptide, corresponding to amino acids 163-208 of Human Caspase 14.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Inflammasonme Signaling,Necrotic Cell Death,