Caspase-4 Inhibitor Z-LEVD-FMK | 1108

A synthetic peptide inhibitor that inhibits caspase-4 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Z-LEVD-FMK is a cell-permeable, irreversible caspase-4 inhibitor.

1108 | Caspase-4 Inhibitor Z-LEVD-FMK DataSheet

Alternate Name/Synonyms: Z-LEVD-FMK, Caspase-4 Inhibitor (fluoromethylketone)

Appearance: Liquid

Formulation: DMSO (2 mM)

CAS Number: N/A

Structure Available?: No

Peptide sequence: Z-Leu-Glu(OMe)-Val-Asp(OMe)-FMK

Salt Form: No

Molecular Formula: C₃₁H₄₅FN₄O₁₀

Molecular Weight: 652.7

Cell-Permeable?: Yes

Purity: >95% by HPLC

Solubilities: N/A

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A caspase-4 inhibitor

MDL Number: N/A

PubChem CID: 44135220

SMILES: CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C31H45FN4O10/c1-18(2)14-23(35-31(43)46-17-20-10-8-7-9-11-20)29(41)33-21(12-13-25(38)44-5)28(40)36-27(19(3)4)30(42)34-22(24(37)16-32)15-26(39)45-6/h7-11,18-19,21-23,27H,12-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)

InChi Key: WGJLXPZGHLANRB-UHFFFAOYSA-N