Caspase 5 p20 (D121) polyclonal Antibody | BS7048

Caspase 5 p20 (D121) polyclonal Antibody | BS7048 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Caspase-5 p20 (D121) polyclonal Antibody detects endogenous levels of the large subunit of active caspase-5 resulting from cleavage at Asp121.

Molecular Weight: ~ 20, 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Caspase-5; CASP-5; ICE (rel) -III; Protease ICH-3; Protease TY; Caspase-5 subunit p20; CASP5; ICH3; Caspase5

Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Caspase-5.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: