Caspase-8 (phospho-S347) polyclonal Antibody | BS4220

Caspase-8 (phospho-S347) polyclonal Antibody | BS4220 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse, (Rat)

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition) . Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Caspase-8 (S347) pAb detects endogenous levels of Caspase-8 protein only when phosphorylated at Ser347.

Molecular Weight: ~ 38, 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Caspase-8; Caspase8; Caspase 8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH; Caspase-8 subunit p18; Caspase-8 subunit p10; CASP8; MCH5

Immunogen: Synthetic phosphopeptide derived from human Caspase-8 around the phosphorylation site of Serine 347.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A