Caspase-9 (phospho-T125) polyclonal Antibody | BS4221

Caspase-9 (phospho-T125) polyclonal Antibody | BS4221 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: Caspase 9 (also known as ICE like apoptotic protease 6 (ICE LAP6), apoptotic protease Mch6, and apoptotic protease activating factor 3 (Apaf3) ) is a member of the peptidase family C14 that contains a CARD domain. This caspase is active as a heterotetramer and has been reported to have two isoforms. ProCaspase 9 has been reported to be approximately 47 kD. This caspase is present in the cytosol and, upon activation, translocates to the mitochondria. Caspase 9 is involved in the caspase activation cascade responsible for apoptosis execution and cleaves/activates Caspase 3 and Caspase 6.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Caspase-9 (T125) polyclonal Antibody detects endogenous levels of Caspase-9 protein only when phosphorylated at Thr125.

Molecular Weight: ~ 35,48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CASP 9; Caspase9; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6; Caspase-9 subunit p35; Caspase-9 subunit p10; CASP9; MCH6

Immunogen: Synthetic phosphopeptide derived from human Caspase-9 around the phosphorylation site of Threonine 125.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,Regulation of Apoptosis,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,