Caspr2 Polyclonal Antibody | BS65669

Caspr2 Polyclonal Antibody | BS65669 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat,

Application: FCM,

Application Range: Flow-Cyt=1ug/Test

Background: CASPR is a transmembrane glycoprotein of the neurexin superfamily that is highly enriched in regions of myelinated axons. The axons of myelinated nerves in the adult nervous system possess specialized subcellular structures essential for efficient and rapid action potential propagation. CASPR and the closely related molecule CASPR2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. While CASPR is present at the paranodal junctions, CASPR2 is precisely colocalized with Shaker-like K+ channels in the juxtaparanodal region. CASPR2 specifically associates with Kv1.1, Kv1.2, and their Kvbeta2 subunit. CASPR family members may play a role in the local differentiation of the axon into distinct functional subdomains.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Caspr2 Polyclonal Antibody detects endogenous levels of Caspr2 protein.

Molecular Weight: 145kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cell recognition molecule Caspr2; Cntnap2; CNTP2; CNTP2_HUMAN; Contactin-associated protein-like 2.

Immunogen: KLH conjugated synthetic peptide derived from human Caspr2

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: