CATB Antibody (Center) [APR32426G]

CATB Antibody (Center) [APR32426G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CATB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the Central region of human CATB.

Cellular Localisation: Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity) {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065}

Molecular Weight: 37822

Clone: Polyclonal

Gene Name: CTSB

Gene ID: 1508

Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505) . Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505) . Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity) . Has also been implicated in tumor invasion and metastasis (PubMed:3972105) .

Summary: Tissue Location: Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Cathepsin B, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB