Catenin-α1 polyclonal Antibody | BS6976

Catenin-α1 polyclonal Antibody | BS6976 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB,IHC

Application Range: WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Background: α E-catenin (also designated α-catenin; cadherin-associated protein, alpha 1, 102kDa; and CAP102) plays a role in E-cadherin mediated cell-cell adhesion by linking E-cadherin to the cytoskeleton via β- or γ-catenin and Actin. α E-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and may provide a negative feedback loop controlling the size of developing cerebral cortex. It is abundant in neuroepithelial precursor cells in the developing cortical ventricular zone of the brain, with reduced expression in the cortical plate. α E-catenin-vinculin interactions play a role in the assembly of the apical junction complex in epithelia. Catenins generally are thought to work as connectors that anchor E-cadherin to the cytoskeletal Actin bundle through the cadherin cytoplasmic domain. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, and is thus considered a contributing factor to metastasis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Catenin-α1 polyclonal Antibody detects endogenous levels of Catenin-α1 protein.

Molecular Weight: ~ 115kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Catenin alpha-1; Alpha E-catenin; Cadherin-associated protein; Renal carcinoma antigen NY-REN-13; CTNNA1; Catenin-α1; Catenin α1; αE-catenin; Catenin alpha-2; Alpha N-catenin; Alpha-catenin-related protein; CTNNA2; CAPR; Catenin-α2; Catenin α2; αN-catenin;

Immunogen: Recombinant full length Human Catenin-α1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: