Catenin-β (phospho-T41/S45) polyclonal Antibody | BS4030

Catenin-β (phospho-T41/S45) polyclonal Antibody | BS4030 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Catenin-β (T41+S45) polyclonal Antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Thr41+S45 .

Molecular Weight: ~ 92 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Catenin β; Cateninβ; Catenin beta-1; Beta-catenin; CTNNB1; CTNNB; ORF Names: OK/SW-cl.35; PRO2286

Immunogen: A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of Human Catenin-β.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: