Cathepsin G Inhibitor | 1982

A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and Ki = 63 nM). Acts as a weak inhibitor of chymotrypsin (Ki = 1.5 µM), thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ > 100 µM).

Cathepsin G inhibitor is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and Ki = 63 nM). Acts as a weak inhibitor of chymotrypsin (Ki = 1.5 µM), thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ > 100 µM).

1982 | Cathepsin G Inhibitor DataSheet

Alternate Name/Synonyms:

Appearance: White solid

Formulation: N/A

CAS Number: 429676-93-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₆H₃₃N₂O₆P

Molecular Weight: 620.63

Cell-Permeable?: No

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A potent Cathepsin G inhibitor

MDL Number: MFCD00130750

PubChem CID: 9830518

SMILES: CN(C1CCN(CC1)C(=O)C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4C=C3C(=O)C(C5=CC=CC6= CC=CC=C65)P(=O)(O)O

InChi: InChI=1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25) 36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42, 43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3, (H2,42,43,44)

InChi Key: GNOZQRKYZJSIPZ-UHFFFAOYSA-N