CATSPER1 polyclonal Antibody | BS60723

CATSPER1 polyclonal Antibody | BS60723 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: CatSper is an ion transport protein located on the surface of sperm cells. CatSper (for cation channel of sperm) is vital to cAMP-mediated calcium influx in sperm, sperm motility and fertilization. The gene that encodes CatSper maps to human chromosome 11q12.1. The 686 amino acid protein is a single, six-transmembrane-spanning protein of the voltage- dependent Ca2+ channel four-repeat structure and is expressed exclusively in the testis. In CatSper -/- sperm, neither cAMP nor cGMP elicit a significant Ca2+ influx in both mutant and wild-type sperm. CatSper is localized to the sperm flagellum and CatSper -/- mice show sluggish and less directed movements. CatSper is required to penetrate the egg, but is not required for egg activation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CATSPER1 polyclonal Antibody detects endogenous levels of CATSPER1 protein.

Molecular Weight: ~ 90 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cation channel sperm-associated protein 1; CatSper1; hCatSper; CATSPER1

Immunogen: A synthetic peptide corresponding to residues in Human CATSPER1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: