CAY10575 | B2912

CAY10575 is an inhibitor of IKK-ε. IKK-ε is a homolog of IKK-α and IKK-β which can activate NF-κB. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC₅₀ value of ~15.8 µM.

CAY10575 is an inhibitor of IKK-ε. IKK-ε is a homolog of IKK-α and IKK-β which can activate NF-κB. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC₅₀ value of ~15.8 µM.

B2912 | CAY10575 DataSheet

Alternate Name/Synonyms: 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(4-methylsulfonylphenyl)methoxy]thiophene-2-carboxamide; BMCL191018 Compound 39; BDBM27444

Appearance: A crystalline solid

Formulation:

CAS Number: 916985-21-2

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₂H₂₁N₃O₆S₂

Molecular Weight: 487.6

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~10 mg/ml in in DMSO, ~1 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of IKK-ε

MDL Number: MFCD10567699

PubChem CID: 25190912

SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=C(C=C4)S(=O)(=O)C)OC

InChi: InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)

InChi Key: