Description
CAY10602 is an activator of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. SIRT1 alters gene expression by deacetylating transcription factors such as NF-κB, p53, and FOXO. CAY10602 suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells at 20 μM and 60 μM. It is more potent as a suppressor of TNF-α release than resveratrol.
CAY10602 is an activator of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. SIRT1 alters gene expression by deacetylating transcription factors such as NF-κB, p53, and FOXO. CAY10602 suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells at 20 μM and 60 μM. It is more potent as a suppressor of TNF-α release than resveratrol.
Alternate Name/Synonyms: 3-(benzenesulfonyl)-1-(4-fluorophenyl)pyrrolo[3,2-b]quinoxalin-2-amine; 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo(2,3-B)quinoxalin-2-amine; SIRT1 Activator II
Appearance: A crystalline solid
Formulation:
CAS Number: 374922-43-7
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₂H₁₅FN₄O₂S
Molecular Weight: 418.4
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~20 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An activator of SIRT1
MDL Number: MFCD02236691
PubChem CID: 1915791
SMILES: C1=CC=C(C=C1)S(=O)(=O)C2=C(N(C3=NC4=CC=CC=C4N=C23)C5=CC=C(C=C5)F)N
InChi: InChI=1S/C22H15FN4O2S/c23-14-10-12-15(13-11-14)27-21(24)20(30(28,29)16-6-2-1-3-7-16)19-22(27)26-18-9-5-4-8-17(18)25-19/h1-13H,24H2
InChi Key:
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |
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