CAY10603 | B2819

CAY10603 is a selective inhibitor of Histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of HDAC6 is 2 pM, in vitro. CAY10603 inhibited growth of various pancreatic cell lines with IC₅₀ values ranging from 0.1 μM to 1 μM. It induced apoptosis and inhibited the proliferation of lung adenocarcinoma cells.

CAY10603 is a selective inhibitor of Histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of HDAC6 is 2 pM, in vitro. CAY10603 inhibited growth of various pancreatic cell lines with IC₅₀ values ranging from 0.1 μM to 1 μM. It induced apoptosis and inhibited the proliferation of lung adenocarcinoma cells.

B2819 | CAY10603 DataSheet

Alternate Name/Synonyms: HDAC6 Inhibitor, tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate, tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate, {4-[3-(6-Hydroxycarbamoylhexylcarbamoyl)isoxazol-5-yl]phenyl}carbamic acid tert-butyl ester, Histone Deacetylase Inhibitor VIII

Appearance: Crystalline solid

Formulation:

CAS Number: 1045792-66-2

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₂H₃₀N₄O₆

Molecular Weight: 446.50

Cell-Permeable?: True

Purity: >98%

Solubilities: ~15 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective inhibitor of HDAC6

MDL Number: MFCD17010286

PubChem CID: 24951314

SMILES: CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO

InChi: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)

InChi Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N