CAY10683 | B1051

CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca. It inhibits HDAC2 and HDAC6 with IC₅₀ values of 0.119 and 434 nM, respectively. Inhibits HDAC4 only at higher concentrations (IC₅₀ = >1,000 nM). CAY10683 inhibits the growth of HCT-116 colon cancer cells and HuT-78 cutaneous T cell lymphoma cells (GI₅₀ = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI₅₀ = >100 μM.

CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca. It inhibits HDAC2 and HDAC6 with IC₅₀ values of 0.119 and 434 nM, respectively. Inhibits HDAC4 only at higher concentrations (IC₅₀ = >1,000 nM). CAY10683 inhibits the growth of HCT-116 colon cancer cells and HuT-78 cutaneous T cell lymphoma cells (GI₅₀ = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI₅₀ = >100 μM.

B1051 | CAY10683 DataSheet

Alternate Name/Synonyms: EthylN-[4-oxo-4-(2-phenylethylamino)butyl]carbamate; Santacruzamate A

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1477949-42-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₂₂N₂O₃

Molecular Weight: 278.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent histone deacetylase (HDAC) inhibitor

MDL Number: N/A

PubChem CID: 72946782

SMILES: CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1

InChi: InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)

InChi Key: HTOYBIILVCHURC-UHFFFAOYSA-N