CAY10685 | B2842

CAY10685 is an active clickable analog of the lysine acetyltransferase inhibitor 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (CPTH2 hydrochloride). The alkyne moiety reacts with an azide group upon copper exposure which tags the “clickable” molecules in cells. N-acetyltransferase 10 (NAT10) is a specific target of CAY10685. The inhibitor is used to study NAT10, it's role in nuclear architecture and for strategies to treat laminopathies and aging.

CAY10685 is an active clickable analog of the lysine acetyltransferase inhibitor 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (CPTH2 hydrochloride). The alkyne moiety reacts with an azide group upon copper exposure which tags the “clickable” molecules in cells. N-acetyltransferase 10 (NAT10) is a specific target of CAY10685. The inhibitor is used to study NAT10, it's role in nuclear architecture and for strategies to treat laminopathies and aging.

B2842 | CAY10685 DataSheet

Alternate Name/Synonyms: 4-(4-chlorophenyl)-N-(cyclopentylideneamino)-N-prop-2-ynyl-1,3-thiazol-2-amine; 4-(4-chlorophenyl)-2-(2-cyclopentylidene-1-(prop-2-yn-1-yl)hydrazinyl)thiazole; Click Tag™ CAY10685

Appearance: A crystalline solid

Formulation:

CAS Number: 1613116-16-7

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₇H₁₆ClN₃S

Molecular Weight: 329.85

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~10 mg/ml in DMF in 0, ~3 mg/ml in in Ethanol, ~5 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An active clickable analog of the lysine acetyltransferase inhibitor CPTH2

MDL Number:

PubChem CID: 91971304

SMILES: C#CCN(C1=NC(=CS1)C2=CC=C(C=C2)Cl)N=C3CCCC3

InChi: InChI=1S/C17H16ClN3S/c1-2-11-21(20-15-5-3-4-6-15)17-19-16(12-22-17)13-7-9-14(18)10-8-13/h1,7-10,12H,3-6,11H2

InChi Key: JDLMHEOHMFFSDW-UHFFFAOYSA-N