CB-1158 | B2228

CB-1158 (INCB001158) is a potent, and selective inhibitor of human arginase I (IC₅₀ = 98 nM), an immune-mediated anti-tumor agent. Displays potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, etc.

CB-1158 (INCB001158) is a potent, and selective inhibitor of human arginase I (IC₅₀ = 98 nM), an immune-mediated anti-tumor agent. Displays potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, etc.

B2228 | CB-1158 DataSheet

Alternate Name/Synonyms: 2-Amino-6-borono-2-(1-(2,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid; INCB001158

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 2095732-06-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₂₂BN₃O₅

Molecular Weight: 287.12

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, and selective human arginase I inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: ClC1=CC(Cl)=CC=C1CN2CCC(C(N)(CCCCB(O)O)C(O)=O)CC2

InChi: InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(16(21)11-15)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)

InChi Key: ISYBHIALKUAHGV-UHFFFAOYSA-N