CB-1158 dihydrochloride | B2554

CB-1158 dihydrochloride (INCB01158 dihydrochloride) is a potent nhibitor of arginase, with IC₅₀s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively.

CB-1158 dihydrochloride (INCB01158 dihydrochloride) is a potent nhibitor of arginase, with IC₅₀s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively.

B2554 | CB-1158 dihydrochloride DataSheet

Alternate Name/Synonyms: (3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid, dihydrochloride; INCB01158 (dihydrochloride)

Appearance: Lyophilized solid

Formulation:

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₂₄BCl₂N₃O₅

Molecular Weight: 360.04

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >40 mg/ml in Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent, and selective human arginase I inhibitor

MDL Number:

PubChem CID: N/A

SMILES: Cl.Cl.N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)[C@H](C)N)C(=O)O

InChi: AuxInfo=1/1/N:1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20;24;26/E:(17,18)(19,20);;/it:im;;/rA:26CCCCCCCCCCCBNNNOOOOOHHHClHCl/rB:;s2;s2;;;s1;s3s5;s7;;s6s8p10;s4;s7;s11;s5s6s9;d9;d10;s10;s12;s12;N7;N8;;s23;;s25;/rC:149,-252,0;570,-448,0;570,-334,0;668,-504,0;406,-369,0;298,-221,0;103,-355,0;472,-278,0;207,-401,0;490,-111,0;406,-186,0;668,-617,0;0,-309,0;382,-76,0;298,-334,0;219,-513,0;598,-146,0;466,0,0;570,-674,0;766,-674,0;57,-458,0;570,-221,0;883,-477,0;996,-477,0;887,-393,0;1000,-393,0;

InChi Key: ADSLCSYZAQTXGU-DVVKEHQFSA-N