CB2 Antibody (C-term) [APR11263G]

CB2 Antibody (C-term) [APR11263G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-356 amino acids from the C-terminal region of human CB2.

Cellular Localisation: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons.

Molecular Weight: 39681

Clone: Polyclonal

Gene Name: CNR2

Gene ID: 1269

Function: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Summary: Tissue Location: Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level) . Expressed in skin in suprabasal layers and hair follicles (at protein level) . Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level) . Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000

Synonyms: Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B