CBFA2T2 Antibody | 22-645

CBFA2T2 Antibody | 22-645 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 of human CBFA2T2 (NP_005084.1) .

Research Area: Other

Tested Application: WB, IF

Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: Jurkat

Positive Control 2: Raji

Positive Control 3: HepG2

Positive Control 4: SW620

Positive Control 5: 22Rv1

Positive Control 6: Mouse brain

Molecular Weight: Observed: 72kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: EHT, MTGR1, ZMYND3, p85, protein CBFA2T2, CBFA2/RUNX1 translocation partner 2, ETO homolog on chromosome 2ETO homologous on chromosome 2MTG8-like protein, MTG8-related protein 1, core-binding factor, runt domain, alpha subunit 2; translocated to, 2, myeloid translocation gene-related protein 1, myeloid translocation-related protein 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.