CBFA2T2 Polyclonal Antibody | E-AB-19075

CBFA2T2 Polyclonal Antibody | E-AB-19075 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: AML1 MTG8, cbfa2t2, Core binding factor runt domain alpha subunit 2 translocated to 2, core-binding factor, runt domain, alpha subunit 2, DKFZp313F2116, EHT, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG 8 like protein, MTG 8 related protein 1, MTG8 like protein, MTG8 related protein 1, MTG8-like protein, MTG8-related protein 1, MTG8R, MTGR 1, Myeloid translocation gene related protein 1, Myeloid translocation related protein 1, Myeloid translocation-related protein 1, p85, Protein CBFA2T2, ZMYND 3, ZMYND3

Application: WB, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: N/A

Background: In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Concentration: 1.26 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human CBFA2T2

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:1000-1:5000, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 67 kDa

Molecular Weight(Observed): Refer to figures