CBFA2T3 Antibody [AMM22303G]

CBFA2T3 Antibody [AMM22303G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This CBFA2T3 antibody is generated from a mouse immunized with a recombinant protein between 418-653 amino acids from human CBFA2T3.

Cellular Localisation: [Isoform 1]: Nucleus, nucleolus. Note=The RUNX1- CBFA2T3 fusion protein localizes to the nucleoplasm

Molecular Weight: 71192

Clone: Monoclonal

Gene Name: CBFA2T3

Gene ID: 863

Function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097) . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097) . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity) . Plays a role in granulocyte differentiation (PubMed:15231665) .

Summary: Tissue Location: Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000-1:2000

Synonyms: Protein CBFA2T3, MTG8-related protein 2, Myeloid translocation gene on chromosome 16 protein, hMTG16, Zinc finger MYND domain-containing protein 4, CBFA2T3, MTG16, MTGR2, ZMYND4