CBFb polyclonal Antibody | BS90204

CBFb polyclonal Antibody | BS90204 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Rat

Application: WB IHC FC

Application Range: WB:1:500 IHC:1:50-1:200 FC:1:50-1:100

Background: The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, a and b, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2a subunits, PEBP2aA, PEBP2aB and PEBP2aC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, Runt. This region is involved in DNA binding and heterodimerization with the regulatory b subunit, which facilitates DNA binding of the a subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2b is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2b/CBFB-SMMHC, that is associated with human acute myeloid leukemia.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: CBFb polyclonal Antibody detects endogenous levels of CBFb protein.

Molecular Weight: 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CBF-beta, PEA2-beta, PEBP2-beta, CBFB, CBF b, CBF beta, CBF-beta, CBFB, CBFbeta, Core binding factor beta subunit, core binding factor subunit beta, Core-binding factor subunit beta, PEA 2, PEA2, PEA2 beta, PEA2-beta, PEA2beta, PEBB, PEBP 2B, PEBP2 beta, PEBP2-beta, PEBP2B, PEBP2beta, Polyomavirus enhancer binding protein 2 beta subunit, Polyomavirus enhancer-binding protein 2 beta subunit, SL3 3 enhancer factor 1 beta subunit, SL3 3 enhancer factor 1 subunit beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core binding factor beta subunit, SL3/AKV core-binding factor beta subunit,

Immunogen: Recombinant protein within human CBFb aa 1-200.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: