CBHA | 2284

A potent histone deacetylase (HDAC) inhibitor (ID₅₀ values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively). CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture (0.5-4.0 μM) and completely suppresses neuroblastoma tumor growth in SCID mice at 200 mg/ kg.

CBHA is a potent histone deacetylase (HDAC) inhibitor (ID₅₀ values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively).

2284 | CBHA DataSheet

Alternate Name/Synonyms: N-​hydroxy-​3-​[3-​(hydroxyamino)-​3-​oxo-​1-​propen-​1-​yl]-​benzamide; m-Carboxycinnamic Acid bis-Hydroxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 174664-65-4

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₀H₁₀N₂O₄

Molecular Weight: 222.2

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent HDAC1 and HDAC3 inhibitor

MDL Number: MFCD03453553

PubChem CID: 5353484

SMILES: C1=CC(=CC(=C1)C(=O)NO)C=CC(=O)NO

InChi: InChI=1S/C10H10N2O4/c13-9(11-15)5-4-7-2-1-3-8(6-7)10(14)12-16/h1-6,15-16H,(H,11,13)(H,12,14)/b5-4+

InChi Key: OYKBQNOPCSXWBL-SNAWJCMRSA-N