CBR-5884 | B2543

CBR-5884 is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 33 μM) inhibiting serine synthesis from 3-phosphoglycerate in cells. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity.

CBR-5884 is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 33 μM) inhibiting serine synthesis from 3-phosphoglycerate in cells. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity.

B2543 | CBR-5884 DataSheet

Alternate Name/Synonyms: 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylic acid, ethyl ester

Appearance: Off-white solid

Formulation:

CAS Number: 681159-27-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₂N₂O₄S₂

Molecular Weight: 336.39

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor

MDL Number:

PubChem CID: 4674993

SMILES: CCOC(=O)C1=C(C(=C(S1)NC(=O)C2=CC=CO2)SC#N)C

InChi: InChI=1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)

InChi Key: QBVIRPJBDIZKBC-UHFFFAOYSA-N