CBX2 Antibody (Center) [APR31497G]

CBX2 Antibody (Center) [APR31497G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This CBX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of human CBX2.

Cellular Localisation: Nucleus. Chromosome Note=Localized in distinct foci on chromatin and in chromocenters Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin

Molecular Weight: 56081

Clone: Polyclonal

Gene Name: CBX2

Gene ID: 84733

Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530) . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530) . Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity) . Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity) . Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Chromobox protein homolog 2, CBX2