CC-115 | B2499

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and displays effective reduction of murine PC3 tumor xenografts.

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and displays effective reduction of murine PC3 tumor xenografts.

B2499 | CC-115 DataSheet

Alternate Name/Synonyms: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one; CC115

Appearance: Crystalline solid

Formulation:

CAS Number: 1228013-15-7

Structure Available?: Yeds

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₆N₈O

Molecular Weight: 336.35

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~10 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A dual DNA-PK and mTOR inhibitor

MDL Number:

PubChem CID: 58298318

SMILES: CCN1C(=O)CNC2=NC=C(N=C21)C3=C(N=C(C=C3)C4=NC=NN4)C

InChi: InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)

InChi Key: GMYLVKUGJMYTFB-UHFFFAOYSA-N