CCDC120 Antibody (N-term) [APR03810G]

CCDC120 Antibody (N-term) [APR03810G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CCDC120 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the N-terminal region of human CCDC120.

Cellular Localisation: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Cell projection, neuron projection. Cell projection, growth cone. Endosome Note=Localizes to the subdistal appendages of mother centrioles and proximal ends of both centrioles in interphase cells (PubMed:28422092) Recruited to subdistal appendages by ODF2 (PubMed:28422092) . In differentiating neuroblastoma cells, colocalizes with CYTH2 in both neurite shaft and growth cone areas (PubMed:25326380) . Partially colocalizes with endosomes along neurites in differentiating neuroblastoma cells (PubMed:25326380) .

Molecular Weight: 67567

Clone: Polyclonal

Gene Name: CCDC120

Gene ID: 90060

Function: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092) . Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092) . Recruits NIN and CEP170 to centrosomes (PubMed:28422092) . Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Coiled-coil domain-containing protein 120, CCDC120