CCDC134 Antibody (C-term) [APR15290G]

CCDC134 Antibody (C-term) [APR15290G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CCDC134 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the C-terminal region of human CCDC134.

Cellular Localisation: Nucleus. Cytoplasm. Secreted Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376)

Molecular Weight: 26561

Clone: Polyclonal

Gene Name: CCDC134

Gene ID: 79879

Function: In extracellular secreted form, promotes proliferation and activation of CD8 (+) T cells, suggesting a cytokine-like function (PubMed:25125657) . Enhances cytotoxic anti-tumor activity of CD8 (+) T cells (PubMed:25125657) . May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808) . May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808) .

Summary: Tissue Location: Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808) . Also detected in placenta (PubMed:18087676) . Highest expression in testis relative to other tissues (PubMed:18087676) . Detected in T cells and dendritic cells; highly expressed in activated CD8 (+) T cells, and also expressed at lower levels in CD4 (+) T cells (PubMed:25125657)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Coiled-coil domain-containing protein 134, CCDC134