CCDC61 Antibody (N-term) [APR03583G]

CCDC61 Antibody (N-term) [APR03583G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CCDC61 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human CCDC61.

Cellular Localisation: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body Note=Localization at the centriolar satellite is dependent on intact microtubule network (PubMed:30354798) . Localizes at the centriole subdistal appendages and proximal ends (PubMed:31789463) . Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2 (PubMed:30354798) .

Molecular Weight: 57368

Clone: Polyclonal

Gene Name: CCDC61 (HGNC:33629)

Gene ID: 729440

Function: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463) . In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463) . During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798) . Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798) . However, this function could not be confirmed (PubMed:31789463) . Plays a non- essential role in ciliogenesis (PubMed:31789463, PubMed:32375023) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Coiled-coil domain-containing protein 61, CCDC61