CCND3 Antibody [3D7B4] | 14-730

CCND3 Antibody [3D7B4] | 14-730 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: A synthetic peptide of human CCND3

Research Area: Cancer, Cell Cycle

Tested Application: WB

Application: WB: 1:1000 - 1:2000

Specificiy: N/A

Positive Control 1: K-562

Positive Control 2: HeLa

Positive Control 3: Mouse thymus

Positive Control 4: Rat thymus

Positive Control 5: Rat lung

Positive Control 6: Rat heart

Molecular Weight: Observed: 32kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Monoclonal

Clone: [3D7B4]

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CCND3,

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.