CCT-129202 | B1934

CCT-129202 is a potent, ATP-competitive inhibitor of Aurora kinases with IC₅₀ values of 42 nM, 198 nM and 227 nM for Aurora A, B and C, respectively. CCT-129202 displays high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.

CCT-129202 is a potent, ATP-competitive inhibitor of Aurora kinases with IC₅₀ values of 42 nM, 198 nM and 227 nM for Aurora A, B and C, respectively. CCT-129202 displays high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines.

B1934 | CCT-129202 DataSheet

Alternate Name/Synonyms: 2-[4-[6-chloro-2-[4-(dimethylamino)phenyl]-1H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(1,3-thiazol-2-yl)acetamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 942947-93-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅ClN₈OS

Molecular Weight: 497.02

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive inhibitor of Aurora kinases

MDL Number: N/A

PubChem CID: 16202152

SMILES: CN(C)C1=CC=C(C=C1)C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC(=O)NC5=NC=CS5)Cl

InChi: InChI=1S/C23H25ClN8OS/c1-30(2)16-5-3-15(4-6-16)21-28-19-20(17(24)13-26-22(19)29-21)32-10-8-31(9-11-32)14-18(33)27-23-25-7-12-34-23/h3-7,12-13H,8-11,14H2,1-2H3,(H,25,27,33)(H,26,28,29)

InChi Key: QYKHWEFPFAGNEV-UHFFFAOYSA-N