CCT-241736 | B2370

CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC₅₀ values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I.

CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC₅₀ values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including FLT3-ITD, -D835Y, -D835H, -K663Q and -N841I.

B2370 | CCT-241736 DataSheet

Alternate Name/Synonyms: CCT241736, 6-chloro-7-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine

Appearance: Crystalline solid

Formulation:

CAS Number: 1402709-93-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₂₃Cl₂N₇

Molecular Weight: 456.38

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent dual FLT3-Aurora inhibitor

MDL Number:

PubChem CID: 454279

SMILES: CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C

InChi: InChI=1S/C22H23Cl2N7/c1-14-17(13-29(2)28-14)21-26-19-20(18(24)11-25-22(19)27-21)31-9-7-30(8-10-31)12-15-3-5-16(23)6-4-15/h3-6,11,13H,7-10,12H2,1-2H3,(H,25,26,27)

InChi Key: AKJBLKUZXRMECW-UHFFFAOYSA-N