CCT-245737 | B2116

CCT-245737 is a potent and selective checkpoint kinase 1 (Chk1) inhibitor, with an IC₅₀of 1.3 nM; displays weaker activity against Chk2 (IC₅₀of 2440 nM).

CCT-245737 is a potent and selective checkpoint kinase 1 (Chk1) inhibitor, with an IC₅₀of 1.3 nM; displays weaker activity against Chk2 (IC₅₀of 2440 nM).

B2116 | CCT-245737 DataSheet

Alternate Name/Synonyms: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1489389-18-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₆F₃N₇O

Molecular Weight: 379.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective checkpoint kinase 1 (Chk1) inhibitor

MDL Number: N/A

PubChem CID: 72165232

SMILES: C1COC(CN1)CNC2=CC(=NC=C2C(F)(F)F)NC3=NC=C(N=C3)C#N

InChi: InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1

InChi Key: YBYYWUUUGCNAHQ-LLVKDONJSA-N