CCT-251545 | B2501

CCT-251545 is a potent Wnt signaling inhibitor (IC₅₀ = 5 nM). It is a selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT-251545 alters Wnt pathway-regulated gene expression. CCT-251545 demonstrates weak inhibition of tankyrase enzymes (TNKS1 IC50 > 10 μM, TNKS2 IC50 = 15.0 ± 0 μM).

CCT-251545 is a potent Wnt signaling inhibitor (IC₅₀ = 5 nM). It is a selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT-251545 alters Wnt pathway-regulated gene expression. CCT-251545 demonstrates weak inhibition of tankyrase enzymes (TNKS1 IC50 > 10 μM, TNKS2 IC50 = 15.0 ± 0 μM).

B2501 | CCT-251545 DataSheet

Alternate Name/Synonyms: CCT251545; 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one

Appearance: Crystalline solid

Formulation:

CAS Number: 1661839-45-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₄ClN₅O

Molecular Weight: 421.93

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >40 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent wnt signaling inhibitor

MDL Number:

PubChem CID: 77050682

SMILES: CN1C=C(C=N1)C2=CC=C(C=C2)C3=CN=CC(=C3N4CCC5(CCNC5=O)CC4)Cl

InChi: InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)

InChi Key: LBFYQISQYCGDDW-UHFFFAOYSA-N