CCT244747 | 9575

CCT244747 is a potent, selective and ATP-competitive CHK1 inhibitor. CCT244747 inhibits cellular CHK1 activity (IC₅₀ = 29-170 nmol/L), significantly enhances the cytotoxicity of several anticancer drugs, and abrogates drug-induced S and G(2) arrest in multiple tumor cell lines.

CCT244747 is a potent, selective and ATP-competitive CHK1 inhibitor. CCT244747 inhibits cellular CHK1 activity (IC₅₀ = 29-170 nmol/L), significantly enhances the cytotoxicity of several anticancer drugs, and abrogates drug-induced S and G(2) arrest in multiple tumor cell lines.

9575 | CCT244747 DataSheet

Alternate Name/Synonyms: (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1404095-34-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄N₈O₂

Molecular Weight: 408.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO ~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective and ATP-competitive CHK1 inhibitor

MDL Number: N/A

PubChem CID: 54758482

SMILES: CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C(C(=C2)OC)C3=CN(N=C3)C

InChi: InChI=1S/C20H24N8O2/c1-13(11-27(2)3)30-20-16(7-21)22-10-19(26-20)25-18-6-17(29-5)15(9-23-18)14-8-24-28(4)12-14/h6,8-10,12-13H,11H2,1-5H3,(H,23,25,26)/t13-/m1/s1

InChi Key: IENLGMOXAQMNEH-CYBMUJFWSA-N