CD1.1 Antibody [CB3] (Biotin) | 99-335

CD1.1 Antibody [CB3] (Biotin) | 99-335 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Chicken

Homology: N/A

Immunogen: Lymphocytes from the bursa of Fabricius of outbred chickens

Research Area: Immunology

Tested Application: Flow

Application: CD1.1 Antibody [CB3] for use in flow cytometry, immunohistochemistry / immunocytochemistry, and immunoprecipitation assays.

Specificiy: CD1.1

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [CB3]

Isotype: IgG1

Conjugate: Biotin

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: N/A

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD1 molecules, like MHC I and II, play an important role in the immune system by presenting lipid, glycolipid and lipopeptide antigen to T and NKT cells. The chicken CD1 gene is located in the chicken MHC B locus and has an important implication for the primordial MHC gene evolution. Two proteins have been identified - CD1.1 and CD1.2. Analysis of RNA from blood cells showed that both genes are expressed in Bu-1+ cells and CD8alpha+ cells. CD1.2 is expressed in TCRgammadelta cells but is nearly undetectable in TCRalphabeta. The monoclonal antibody CB3 antibody can identify cells of the B cell lineage and recognizes CD1.1 but not CD1.2 on the surface of transfected mammalian cells.