CD130 Antibody (C-term) [APR03528G]

CD130 Antibody (C-term) [APR03528G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CD130 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 871-899 amino acids from the C-terminal region of human CD130.

Cellular Localisation: [Isoform 1]: Cell membrane; Single-pass type I membrane protein

Molecular Weight: 103537

Clone: Polyclonal

Gene Name: IL6ST (HGNC:6021)

Gene ID: 3572

Function: Signal-transducing molecule (PubMed:2261637) . The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003) . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159) . In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity) . Also activates the yes- associated protein 1 (YAP) and NOTCH pathways to control inflammation- induced epithelial regeneration, independently of STAT3 (By similarity) . Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed:19386761) . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity) . Has a role in embryonic development (By similarity) . Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity) . Required for expression of TRPA1 in nociceptive neurons (By similarity) . Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity) . Required for normal trabecular bone mass and cortical bone composition (By similarity) .

Summary: Tissue Location: Found in all the tissues and cell lines examined (PubMed:2261637) . Expression not restricted to IL6 responsive cells (PubMed:2261637) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:2000

Synonyms: Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130, IL6ST