CD152 [CTLA-4] non-lytic Recombinant Protein | 90-419

CD152 [CTLA-4] non-lytic Recombinant Protein | 90-419 | Gentaur UK, US & Europe Distribution

Tested Application: N/A

Application: This recombinant proteins is for research use only.

Tpredicted Molecular Weight: N/A

Physical State: Lyophilized

Buffer: Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.

Alternate Name: CTLA-4

Background: N/A

Shipping: N/A

Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

Source: NS1 cells

Species: Mouse

By Source: Other

By Species: Mouse

Fusion Tag: Fc Tag

Sequence: The extracellular domain of mouse CD152 [CTLA-4] (aa 1-160) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.

Bological Activity: Blocks the binding of mouse CD80 (B7-1) and CD86 (B7-2) to their receptors (by binding CD80 and CD86 with high affinity) and thereby prevents their T cell regulatory actions by inhibiting the CD28 signaling competitively. Shows the biological functions of the CD152 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. Useful for investigating the T cell co-stimulation.

Purity: >98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).