CD154 Antibody [MR1] | 98-773

CD154 Antibody [MR1] | 98-773 | Gentaur UK, US & Europe Distribution

Host: Hamster

Reactivity: Mouse

Homology: N/A

Immunogen: Activated mouse Th1 clone D1.6

Research Area: Immunology

Tested Application: WB, IHC-P, IHC-Fr, ICC, Flow, IP, Adhesion

Application: CD154 Antibody [MR1] for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, and blocking assays.

Specificiy: CD154

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [MR1]

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in PBS

Concentration: 0.5 mg/mL

Storage Condition: Store vial at -20˚C

Alternate Name: CD40L, CD40 ligand, gp39

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. It is an important accessory molecule in T cell-B cell costimulatory interactions and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporin-sensitive. The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens yet does not alter the immune response to TI antigens.