CD161 (3F8) monoclonal Antibody | MB8565

CD161 (3F8) monoclonal Antibody | MB8565 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Rat

Application: WB

Application Range: WB: 1:500~1:2000 IHC: 1:50~1:200

Background: Natural killer (NK) and T cells express a superfamily of proteins with structural features of C-type lectins. T cells bearing natural killer receptors (NKRs) such as CD94 and CD161 are present in psoriasis. CD161 mediates NK cell activation and functions as an activating receptor. CD161 is a prototypic marker of NK cells, although it is also found on a subset of CD8+ T cells. The expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector T cells that are expanded in vivo after antigenic activation leading to extensive proliferation. The transcription, mRNA accumulation, and surface expression of CD161, a molecule involved in triggering cytotoxicity, is specifically upregulated by IL-12.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD161 (3F8) mAb detects endogenous levels of CD161 protein.

Molecular Weight: ~ 25 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161

Immunogen: Synthetic peptide, corresponding to amino acids of Human CD161.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,