CD177 polyclonal Antibody | BS6857

CD177 polyclonal Antibody | BS6857 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Patients with polycythemia vera (PV), a neoplastic stem cell disorder that leads to excessive production of all myeloid cell lines, overexpress the cell surface antigen CD177, also designated NB1. The increased output, especially of red blood cells, increases whole blood viscosity and causes vascular occlusion and ischemia. Because of the marked upregulation of CD177 in PV patients, as compared to healthy individuals or those with other erythrocytosis-related conditions, analysis of this protein presents a useful tool for diagnosis and research into the mechanisms of PV.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CD177 polyclonal Antibody detects endogenous levels of CD177 protein.

Molecular Weight: ~ 46 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD177 antigen; Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD177; CD177; NB1; PRV1; UNQ595; PRO1181

Immunogen: Recombinant full length Human CD177.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: