CD18 Antibody [M18/2] | 76-723

CD18 Antibody [M18/2] | 76-723 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: N/A

Research Area: Cancer, Functional Assays

Tested Application: Flow, Func

Application: N/A

Specificiy: The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Clonality: Monoclonal

Clone: M18/2

Isotype: Rat IgG2a, kappa

Conjugate: Unconjugated

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C . Do not freeze.

Alternate Name: 2E6, LAD, Cd18, Lfa1, MF17, LCAMB, AI528527, Itgb2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.