CD19 Antibody (C-term) [APR04044G]

CD19 Antibody (C-term) [APR04044G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CD19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-421 amino acids from the C-terminal region of human CD19.

Cellular Localisation: Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918}

Molecular Weight: 61128

Clone: Polyclonal

Gene Name: CD19

Gene ID: 930

Function: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701) . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca (2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701) . Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126) . Required for normal differentiation of B-1 cells (By similarity) . Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518) . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701) .

Summary: Tissue Location: Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100) . Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, CD19, CD19