CD1a polyclonal Antibody | BS90223

CD1a polyclonal Antibody | BS90223 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB:1:500 IHC:1:50-1:200

Background: The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CD1a polyclonal Antibody detects endogenous levels of CD1a protein.

Molecular Weight: 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hTa1 thymocyte antigen, CD1a, CD1A, CD 1a, CD1, CD1a, CD1A Antigen, CD1A antigen, a polypeptide, CD1a molecule, CD1A, cluster of differentiation 1 A, cortical thymocyte antigen CD1A, differentiation antigen CD1 alpha 3, epidermal dendritic cell marker CD1a, FCB 6, FCB6, HTA 1, HTA1, hTa1 thymocyte antigen, OTTHUMP00000018907, R 4, R4, T 6, T-cell surface antigen T6/Leu-6, T-cell surface glycoprotein CD1a, T6,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: Tumor-Infiltrating Immune Cell Marker Guide,