CD23 Antibody [2G8] (Biotin) | 98-685

CD23 Antibody [2G8] (Biotin) | 98-685 | Gentaur UK, US & Europe Distribution

Host: Rat

Reactivity: Mouse

Homology: N/A

Immunogen: FcepsilonR isolated from B cell lymphoma cell line M12.4.5

Research Area: Immunology, Stem Cell, Cancer, Cell Cycle

Tested Application: Flow

Application: CD23 Antibody [2G8] for use in flow cytometry, ELISA, and immunohistochemistry assays.

Specificiy: CD23

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [2G8]

Isotype: IgG2a

Conjugate: Biotin

Physical State: Liquid

Buffer: Supplied in PBS/NaN3

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: FcepsilonRII, BLAST-2, low affinity IgE receptor, Ly-42

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The CD23 antigen is the low affinity IgE Fc receptor, which is a 45-49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells) and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a ���membrane bound cytokine, " in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.