CD26 polyclonal Antibody | BS90227

CD26 polyclonal Antibody | BS90227 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB,IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: CD26 (dipeptidylpeptidase 4, adenosine deaminase complexing protein 2, ADABP, ADCP2, DPPIV, TP103) is a membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. CD26 has an essential role in immune regulation as a T cell activation molecule and a regulator of chemokine function. CD26 associates with CXCR4 and gp120 and may influence the pathophysiology of HIV infection. Adenosine deaminase (ADA) colocalizing with adenosine receptors on dendritic cells are able to interact with CD26 expressed on lymphocytes. This costimulatory signal in the immunological synapse leads to an increase in the production of the T helper 1 and proinflammatory cytokines IFN-gamma, TNF-alpha, and IL-6. CD26 plays a role in the pathogenesis and behavior of human cancers, including solid tumors and hematological malignancies. CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: CD26 polyclonal Antibody detects endogenous levels of CD26 protein.

Molecular Weight: 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ADCP-2, DPP IV, DPP4, CD26 antigen, ADA-binding protein, ADABP, ADCP 2, ADCP-2, ADCP2, Adenosine deaminase complexing protein 2, CD 26, CD26, CD26 antigen 3, Dipeptidyl peptidase 4, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase IV soluble form, Dipeptidyl peptidase, intestinal, Dipeptidylpeptidase 4, Dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2), Dipeptidylpeptidase IV, DPP 4, DPP IV, DPP IV estoenzyme, DPP4, DPP4, DPPIV, Intestinal dipeptidyl peptidase, T cell activation antigen CD26, T-cell activation antigen CD26, TP 103, TP103,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: