CD279 Antibody [J43.1] | 76-976

CD279 Antibody [J43.1] | 76-976 | Gentaur UK, US & Europe Distribution

Host: Hamster

Reactivity: Mouse

Homology: N/A

Immunogen: N/A

Research Area: Immunology, Apoptosis, Functional Assays

Tested Application: Flow, IHC, IP

Application: N/A

Specificiy: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1) , a 50-55 kDa glycoprotein of the Ig superfamily.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Clonality: Monoclonal

Clone: J43.1

Isotype: Armenian Hamster IgG

Conjugate: Unconjugated

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C . Do not freeze.

Alternate Name: PD-1, Pdc1, Ly101, Pdcd1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1) , a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.